PRODUCT DETAILS

About Clozine 50mg Tablet

CHLORPROMAZINE belongs to a group of medications called ‘antipsychotics’. It is used in the treatment of schizophrenia or psychosis and bipolar disorder (manic depression). Besides this, it is also used to treat nausea and vomiting, anxiety before surgery, and chronic hiccups (involuntary spasms of the diaphragm). Schizophrenia is characterized by hallucinations symptoms (seeing or hearing things that are not real) and delusions (wrong beliefs). Manic episodes of excitement or depression characterize bipolar disorder. CHLORPROMAZINE prevents the occurrence of these symptoms. 

CHLORPROMAZINE contains ‘Chlorpromazine’ which is an antipsychotic drug. It acts by blocking dopamine, a neurotransmitter present in the brain responsible for developing schizophrenia and bipolar disorder symptoms. CHLORPROMAZINE rebalances dopamine to improve thinking, mood, and behavior. It also blocks the other natural substances receptors in the brain, such as histamine and muscarinic, thereby preventing nausea and vomiting.

Take CHLORPROMAZINE as prescribed by your doctor. You are advised to take CHLORPROMAZINE as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as sleepiness, orthostatic hypotension (sudden lowering of blood pressure on standing), dry mouth, abnormality of voluntary movements, weight gain, urinary retention, constipation, muscle stiffness, and tremor. Most of these side effects of CHLORPROMAZINE do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Do not take CHLORPROMAZINE if you are allergic to Chlorpromazine or any other ingredients present in it. Before taking CHLORPROMAZINE, talk to your doctor if you or your family have a history of blood clots, stroke, or heart disease and if you are above 65 years and have a history of dementia (memory loss). CHLORPROMAZINE is not recommended during pregnancy as it may affect the unborn baby. Tell your doctor if you are breastfeeding before taking CHLORPROMAZINE. It is not recommended for use in children under 1 year of age. CHLORPROMAZINE contains lactose, so it should not be given to people who are intolerant to some sugars. Please do not stop taking CHLORPROMAZINE without your doctor’s advice as it may lead to withdrawal symptoms.

Uses of Clozine 50mg Tablet

Schizophrenia (mental illness), Bipolar disorder (manic depression).

Medicinal Benefits of Clozine 50mg Tablet

CHLORPROMAZINE works by helping to restore the balance of certain natural substances in the brain. The key action of CHLORPROMAZINE is to block the dopamine receptors (D2) in the brain and correct dopamine's overactivity. Altogether, CHLORPROMAZINE may help decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. On the other hand, it also blocks histamine H1 and muscarinic M1 receptors in the vomiting center, thereby preventing nausea and vomiting.

Directions for Use

Oral Tablet: Take CHLORPROMAZINE with or without food as advised by your doctor and swallow it whole with a glass of water. Do not crush, chew or break it. Liquid Oral Syrup: Shake the bottle well before use. Check the label for directions and take CHLORPROMAZINE with or without food in doses as prescribed by your doctor with the help of a measuring cup. Injection: A healthcare professional will administer the injection form of CHLORPROMAZINE, and do not self-administer. Depending on your medical condition, your doctor will decide how long you need to take CHLORPROMAZINE.

Side Effects of Clozine 50mg Tablet

• Sleepiness
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Dry mouth
• Abnormality of voluntary movements,
• Weight gain
• Urinary retention
• Constipation
• Muscle stiffness
• Tremor
• Confusion, agitation, feeling jittery, trouble sleeping
• Tardive dyskinesia (unusual/uncontrolled movements of the face, lips, mouth, tongue, arms, or legs)
• breast swelling or discharge

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take CHLORPROMAZINE if you are allergic (hypersensitive) to CHLORPROMAZINE or any ingredients present in it. Please consult your doctor before taking CHLORPROMAZINE if you are pregnant or planning to conceive and breastfeed. The use of CHLORPROMAZINE should be avoided in children and adolescents whose signs and symptoms suggest Reye’s syndrome (confusion, swelling in the brain, and liver damage). Elderly patients (above 65 years) with dementia-related psychosis (memory loss) treated with antipsychotic drugs, increased the risk of death. CHLORPROMAZINE injection is not recommended for the treatment of patients with dementia-related psychosis. Do not abruptly stop taking the medication as it may cause withdrawal symptoms, especially suicidal thoughts in young adults. If you are an asthmatic patient, please inform your doctor before taking a CHLORPROMAZINE injection as it may cause life-threatening allergic-type reactions, including anaphylactic symptoms. Before taking CHLORPROMAZINE, talk to your doctor if you have a history of blood clots, alcohol or drug abuse, fits (seizures), Parkinson's disease, hypothyroidism (reduced activity of the thyroid gland), stroke or heart diseases, myasthenia gravis (a condition where muscles become easily tired and weak leading to difficulty breathing) and glaucoma (increased pressure in the eye).

Drug Interactions

Drug-Drug Interaction:

CHLORPROMAZINE may interact with some medications, including antidepressants (citalopram, escitalopram, bupropion), medicines for Parkinson’s disease (levodopa), antiepileptic ( carbamazepine, phenobarbital), medicines to control heartbeat ( amiodarone, disopyramide, quinidine), medicines used to calm emotion and mental disorder (olanzapine, prochlorperazine) antihypertensive (clonidine, guanethidine, propranolol), antibiotic (moxifloxacin) and medication used to treat mental illness (lithium).

Drug-Disease Interaction:

 CHLORPROMAZINE should be used with caution in patients with heart problems such as QT prolongation (heart rhythm problem), acute alcohol abuse, central nervous system (CNS) depression, dementia, stroke, seizures, diabetes, and liver problems.

Safety Advice

ALCOHOL

Alcohol may worsen the condition and increase the risk of side effects while using CHLORPROMAZINE.

PREGNANCY

CHLORPROMAZINE is a category C pregnancy drug, using CHLORPROMAZINE during pregnancy may affect the unborn baby. Please consult your doctor before taking CHLORPROMAZINE if you are pregnant or planning to conceive.

BREAST FEEDING

CHLORPROMAZINE is known to pass through breast milk. So, it is recommended not to be taken during breastfeeding. However, your doctor may prescribe it for you during breastfeeding if he/she feels that the benefits to you outweighs the risk.

DRIVING

CHLORPROMAZINE may cause some cases, especially elderly patients, to become drowsy, dizzy, light-headed, clumsy, unsteady, or less alert than normal. If you are affected, do not drive or operate dangerous machinery after taking CHLORPROMAZINE.

LIVER

CHLORPROMAZINE should be used with caution in patients with liver diseases. Dose adjustments may be necessary.

KIDNEY

CHLORPROMAZINE should be used with caution in patients with kidney diseases. Dose adjustments may be necessary.