PRODUCT DETAILS

About Conjugase Tablet

CONJUGATED ESTROGENS is used as ‘hormone replacement therapy to treat symptoms and conditions associated with menopause. During menopause, estrogen levels decrease, leading to hot flushes (feeling of heat over the face, neck, and chest). Women with menopause are at risk of developing osteoporosis (thinning of bones). CONJUGATED ESTROGENS can be used to prevent osteoporosis after menopause.

CONJUGATED ESTROGENS contains ‘conjugated estrogens’ which are used as hormone replacement therapy (HRT). It works by replacing the estrogen hormone in menopausal women. It also regulates the secretions of hormones such as luteinizing hormone (LH) (necessary for sexual function and menstrual cycle) and follicle-stimulating hormone (FSH) (regulates menstrual cycle). These effects help to improve the symptoms of menopause.

CONJUGATED ESTROGENS is available in the form of tablets, injections, and creams. It would be best if you took CONJUGATED ESTROGENS as prescribed by your doctor. The common side-effects of CONJUGATED ESTROGENS are abnormal vaginal bleeding or spotting, vaginal discharge, pain and swelling in the breasts, discharge from the nipples, changes in breast tissue, feeling or being sick, bloating, abdominal pain, headache, dizziness, mood changes, irritability, joint pain, leg cramps, increased or decreased libido (sexual desire), swelling of face or ankles, rashes on the skin, changes in hair growth, eye, weight and triglyceride levels (fats), intolerance to glucose, memory loss and jaundice (yellowing of the skin or eyes).

Do not take CONJUGATED ESTROGENS if you are allergic to ‘conjugated estrogens’ or any ingredients present in it. Also, do not take CONJUGATED ESTROGENS if you have a history of breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), have a blood clot in the veins (thrombosis), in the legs (deep vein thrombosis) or the lungs (pulmonary embolism), blood clotting disorder, heart attack or angina (chest pain), inherited porphyria (a blood disorder) or liver disease. It is not recommended for use in pregnant and breastfeeding women. Stop taking CONJUGATED ESTROGENS and consult your doctor immediately, if you develop jaundice (yellowing of the skin and eyes), high blood pressure and migraine-like headache, become pregnant or notice signs of a blood clot such as redness, swelling, and pain in the legs, sudden chest pain or difficulty in breathing. Inform your doctor if you have any intolerance to sugar.

Uses of Conjugase Tablet

Hormone replacement therapy

Medicinal Benefits of Conjugase Tablet

CONJUGATED ESTROGENS contains ‘conjugated estrogens’ which is a hormone replacement therapy (HRT). In menopause, estrogen levels become too low, so CONJUGATED ESTROGENS works by replacing this hormone.  It also regulates the secretions of other hormones from the pituitary gland such as luteinizing hormone (LH) (necessary for sexual function and menstrual cycle) and follicle-stimulating hormone (FSH) (regulates menstrual cycle). These effects help to reduce the symptoms of menopause.

Directions for Use

CONJUGATED ESTROGENS is available in tablet, topical cream, and injection dosage forms. Tablet: The doctor determines the dose and duration of the medicine. Swallow the tablet as a whole with a glass of water. Do not crush, chew or break it. Take the medication at a fixed time every day for better results. Injection: CONJUGATED ESTROGENS injection is administered using a syringe. It is given by a healthcare professional, so do not self-administer. Topical cream: Clean and dry the affected area. Then, apply a thin layer of the medicine to the affected area. Do not apply to broken skin or open wounds. Wash your hands before and after use.

Side Effects of Conjugase Tablet

Common side effects may include:

• Nausea, gas, stomach pain
• Headache, back pain
• Depression, sleep problems (insomnia)
• Breast pain
• Vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

Serious, but less common side effects include:

• Breast lumps
• Unusual vaginal bleeding
• Changes in vision or speech
• Sudden new severe headaches
• Severe pains in your chest or legs with or without shortness of breath, weakness, and fatigue
• Swollen lips, tongue, or face

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Before taking CONJUGATED ESTROGENS, inform your doctor if you have fibroids inside the womb, growth of womb lining outside the womb (endometriosis), excessive thickening of the womb lining (endometrial hyperplasia), increased risk of developing blood clots, increased risk of getting estrogen-sensitive cancer (in people with a family history of breast cancer), high blood pressure, diseases associated with liver, kidney, or heart, fluid retention (edema), diabetes, gallbladder stones, migraine or severe headache, systemic lupus erythematosus, epilepsy (fits), asthma, a condition affecting eardrum and hearing (osteosclerosis), low calcium levels in the blood (hypocalcemia), and high levels of fat in the blood. CONJUGATED ESTROGENS increases the risk of endometrial hyperplasia and endometrial cancer, so your doctor may prescribe you the hormonal medicine ‘progesterone’ to minimize this risk. The coloring agent in yellow-colored tablets may cause allergic reactions. Inform your doctor if you have any intolerance to sugars as this medicine contains lactose. Inform your doctor if you are pregnant or breastfeeding.

Drug Interactions

Drug-Drug Interaction:

CONJUGATED ESTROGENS may interact with anticonvulsants (phenobarbital, phenytoin, and carbamazepine), medicines used to treat tuberculosis (rifampicin and rifabutin), drugs used to treat HIV (nevirapine, efavirenz, ritonavir, and nelfinavir), antibiotics (erythromycin and clarithromycin), antifungal medicines (ketoconazole and itraconazole), a herbal preparation such as St. John’s wort (Hypericum perforatum), a medicine used to treat Cushing’s syndrome (metyrapone), a drug used to treat stomach ulcers (cimetidine) and corticosteroids (dexamethasone).

Drug-Disease Interaction:

 CONJUGATED ESTROGENS is contraindicated in conditions such as breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), having a blood clot in the veins (thrombosis), in the legs (deep vein thrombosis), or the lungs (pulmonary embolism), blood clotting disorder, heart attack or angina (chest pain), inherited porphyria (a blood disorder), or liver disease.

Safety Advice

ALCOHOL

Consumption of alcohol may worsen the condition by increasing the risk of side effects.

PREGNANCY

CONJUGATED ESTROGENS is a category X drug. This medicine is not recommended for use in pregnant women as it causes fetal abnormalities.

BREAST FEEDING

CONJUGATED ESTROGENS is not recommended for breastfeeding mothers as this medicine can pass into breast milk.

DRIVING

CONJUGATED ESTROGENS may not affect your ability to drive.

LIVER

CONJUGATED ESTROGENS should not be used in patients with liver diseases.

KIDNEY

CONJUGATED ESTROGENS should be used with caution in patients with severe kidney diseases. Dose adjustments may be necessary.