PRODUCT DETAILS

About Posatral Tablet

POSACONAZOLE is in a class of medications called azole antifungals. It is used to prevent and treat many different fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for prophylaxis of invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

POSACONAZOLE contains a medicine called posaconazole. It is a triazole antifungal agent, and it exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to the inhibition of the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibition of fungal cell growth and, ultimately, cell death. Thus, it treats the infections.

Uses of Posatral Tablet

• Fungal infections
• Prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.
• Treatment of oropharyngeal candidiasis (OPC), including OPC refractory (rOPC)

Medicinal Benefits of Posatral Tablet

POSACONAZOLE contains a medicine called posaconazole. This belongs to a group of medicines called “antifungals”. It can be used in adults to treat the following types of fungal infections when other antifungal medicines have not worked or you have had to stop taking them.

• Infections caused by fungi that cause the conditions known as “chromoblastomycosis” and “mycetoma” that have not improved during treatment with itraconazole or when itraconazole has had to be stopped;
• Infections caused by a fungus called Coccidioides have not improved during treatment with one or more amphotericin B, itraconazole or fluconazole or when these medicines have had to be stopped.

POSACONAZOLE can also be used to prevent fungal infections in adults who are at high risk of getting a fungal infection, such as:

• Patients who have a weak immune system due to having chemotherapy for “acute myelogenous leukemia” (AML) or “myelodysplastic syndromes” (MDS)
• Patients having “high-dose immunosuppressive therapy” after “hematopoietic stem cell transplant” (HSCT).

Directions for Use

Always use this medicine exactly as your doctor has told you or as per the package leaflet.

Side Effects of Posatral Tablet

• Diarrhoea
• Nausea
• Fever
• Vomiting
• Headache
• Coughing
• Low potassium levels in the blood

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

If you are known to be allergic to POSACONAZOLE or any other medicines such as have had an allergic reaction to another antifungal medicine such as ketoconazole, fluconazole, itraconazole or voriconazole, or any other medications, please tell your doctor. POSACONAZOLE is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy or a nursing mother, it is advised to consult a doctor before using POSACONAZOLE. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Use of POSACONAZOLE may be contraindicated in people with Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug Interactions

Drug-Drug Interaction:

POSACONAZOLE may interact with various drugs, including terfenadine (used to treat allergies), astemizole (used to treat allergies), cisapride (used to treat stomach problems), pimozide (used to treat symptoms of Tourette's and mental illness), halofantrine (used to treat malaria), and quinidine (used to treat abnormal heart rhythms).

Drug-Disease Interaction:

Tell your doctor before taking POSACONAZOLE if you have a medical history of allergic reactions to medicines, heart diseases, liver or kidney problems, blood disorders and low levels of magnesium and potassium.

Safety Advice

ALCOHOL

You are recommended not to consume alcohol along with POSACONAZOLE to avoid unpleasant side effects.

PREGNANCY

POSACONAZOLE is not recommended during pregnancy. However, your doctor may prescribe it for you during pregnancy if he/she feels that the benefit to you outweighs the risk. You should not take $ name without the doctor's advice.

BREAST FEEDING

There are no studies in nursing women. POSACONAZOLE should be used in nursing women only if the potential benefit outweighs the potential risk to the baby. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.

DRIVING

You may feel dizzy, sleepy, or have blurred vision while using POSACONAZOLE, which may affect your ability to drive or use tools or machines. If this happens, do not drive or use any tools or machines and contact your doctor.

LIVER

If u have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine. You may need to have blood tests while you are taking this medicine.

KIDNEY

If u have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine. Your doctor will weigh the benefits and any potential risks before prescribing them to you.