PRODUCT DETAILS

About Graine Plus 40mg/10mg Tablet SR

FLUNARIZINE+PROPRANOLOL belongs to the class of anti-migraine drugs, primarily used to treat migraine. Migraine is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Its symptoms include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

FLUNARIZINE+PROPRANOLOL consists of two drugs: 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol belongs to the class of beta-blockers. It has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. It is also used to treat peripheral vascular diseases, vertigo (spinning sensation), and adjuvant treatment in treating seizure (fits) disorder.

FLUNARIZINE+PROPRANOLOL is available in oral tablet and capsule formulations. Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of FLUNARIZINE+PROPRANOLOL include dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting FLUNARIZINE+PROPRANOLOL. FLUNARIZINE+PROPRANOLOL may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking FLUNARIZINE+PROPRANOLOL if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with FLUNARIZINE+PROPRANOLOL as it could lead to increased drowsiness.

Uses of Graine Plus 40mg/10mg Tablet SR

Migraine.

Medicinal Benefits of Graine Plus 40mg/10mg Tablet SR

FLUNARIZINE+PROPRANOLOL is used to treat migraine. It consists of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. It works by lowering cerebral (brain) blood flow and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It reduces the severity and frequency of migraine headaches. It is also used to treat and relieve tremors, angina (chest pain), hypertension (high blood pressure), heart rhythm disorders, and anxiety. Flunarizine is a channel blocker that improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. It is also used to treat peripheral vascular diseases, vertigo (spinning sensation), and adjuvant treatment in treating seizure (fits) disorder.

Directions for Use

FLUNARIZINE+PROPRANOLOL is available in oral tablet and capsule form. Tablet/Capsule: Take FLUNARIZINE+PROPRANOLOL with or without food. Swallow FLUNARIZINE+PROPRANOLOL as a whole with a glass of water; do not chew, or break the tablet.

Side Effects of Graine Plus 40mg/10mg Tablet SR

• Weight gain
• Slow heart rate
• Tiredness
• Depression
• Drowsiness
• Abnormal dreams
• Cold extremities (hands and feet)

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Inform your doctor if you have a history of liver or kidney diseases, breathing problems (asthma, bronchitis, emphysema), diabetes, heart failure, heart rhythm problems (sinus bradycardia, Wolff-Parkinson-White syndrome, second- or third-degree atrioventricular block), overactive thyroid (hyperthyroidism), blood circulation problems (Raynaud's disease), adrenal gland tumor (pheochromocytoma), depression, metabolic acidosis (excess acid in the blood), and myasthenia gravis (muscle weakness) before starting FLUNARIZINE+PROPRANOLOL. Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting FLUNARIZINE+PROPRANOLOL.

FLUNARIZINE+PROPRANOLOL can cause weight gain; hence it is advised to maintain a well-balanced, healthy lifestyle. FLUNARIZINE+PROPRANOLOL is not recommended if you are breastfeeding since it is excreted into breast milk. Please consult your doctor if you are pregnant and planning to conceive if the doctor advised you FLUNARIZINE+PROPRANOLOL. Avoid consuming alcohol along with FLUNARIZINE+PROPRANOLOL as it could lead to increased dizziness and drowsiness.

Drug Interactions

Drug-Drug Interaction:

FLUNARIZINE+PROPRANOLOL may interact with mood disorder medicines (alprazolam, quetiapine, aripiprazole), drugs treating sleeping problems (zolpidem), respiratory drugs (diphenhydramine), antidepressants (sertraline, duloxetine, fluoxetine), and fits medicine (carbamazepine, phenytoin).

Drug-Disease Interaction:

 Before using FLUNARIZINE+PROPRANOLOL, let your doctor know if you have any liver, kidney, or heart diseases, asthma, depression, muscle disorders, diabetes, and alcohol dependency.

Safety Advice

ALCOHOL

You are recommended to avoid alcohol consumption while taking FLUNARIZINE+PROPRANOLOL. Alcohol intake, along with FLUNARIZINE+PROPRANOLOL, may cause increased dizziness and drowsiness.

PREGNANCY

It is not recommended to use FLUNARIZINE+PROPRANOLOL during pregnancy. Please consult your doctor if you are pregnant or planning to conceive before using FLUNARIZINE+PROPRANOLOL.

BREAST FEEDING

FLUNARIZINE+PROPRANOLOL is excreted into breast milk when used by a breastfeeding mother. It is not recommended for use during breastfeeding. Please consult your doctor before taking FLUNARIZINE+PROPRANOLOL.

DRIVING

FLUNARIZINE+PROPRANOLOL may make you feel drowsy. Do not drive or operate machinery if you experience drowsiness.

LIVER

Therapy with propranolol should be administered cautiously in patients with liver disease. Please consult your doctor if you have a history of liver impairment/liver disease.

KIDNEY

Plasma clearance of Propranolol in FLUNARIZINE+PROPRANOLOL is reduced in patients with renal failure. Please consult your doctor if you have a history of kidney impairment/kidney disease.